Mahad, or Artocarpus lakoocha Roxb, is a perennial plant of the Moraceae family. It may be found in tropical Asian countries such as India, Myanmar, Thailand, Laos, and Malaysia, among others. It is found in Thailand’s southeastern, southwestern, and southern areas. According to research, the Mahad tree’s heart includes stilbinoids and flavonoids such Resveratrol, Oxyresveratrol, Artocarpin, Norartocarpin, Cycloartocarpin, and Norcycloartocarpin. Mahad essence is used in Thai medicine textbooks as a parasite medication, flatulence, diuretic, expectorant, and can block viruses such as HIV HSV1 and HSV2, as well as bacterium. In the beauty industry, Mahad axis is well-known for being a Whitening agent that inhibits the enzyme tyrosinase in the skin’s melanin synthesis process via Oxyresveratrol. Because oxyresveratrol has more hydroxyl groups than resveratrol, it is more effective as an anti-oxidant and whitening agent than resveratrol.

Oxyresveratrol possesses antioxidant capabilities (anti-oxidation) and inhibits the enzyme tyrosinase. Oxyresveratrol from the heart of Mahad has been discovered to inhibit the enzyme tyrosinase 20 times more than Resveratrol and 20 times more than vitamin C. The outcomes are more rapid and effective than Kojic acid and Licorice Extract. It suppresses the activity of tyrosinase enzymes more than vitamin C (ascorbic acid). Also aids in the fading of the pigment melanin. The antioxidant oxyresveratrol inhibits the action of the enzyme tyrosinase. This will have a direct impact on tyrosinase’s DOPA oxidase activity throughout the melanin production process. It functions as a whitener and anti-dark spot agent, as well as a chemical that promotes anti-aging via the anti-glycation process. Glycation is the bonding of protein substances with proteins and macromolecules that results in the formation of new compounds with hard yet brittle characteristics. By this process, the cells of the aged will be destroyed, resulting in the deterioration of the collagen structure beneath the skin. When the skin loses its suppleness, wrinkles appear. Oxyresveratrol inhibits this as well as boosting hair restoration process.

According to the results of the test, the component Oxyresveratrol from Mahad essence inhibits aggressive melanoma cells. B16F10 melanoma aids in anti-obesity by boosting fat metabolism, as well as anti-inflammatory (Anti-inflammatory) and immune system enhancement. (Immuneregulatory)

Oxyresveratrol The essence of Mahad can be utilised to continue research to strengthen the stability of vital components and to use technology to keep the active elements in the product. In the development of research and natural extracts, TIBD now collaborates with major research institutes both locally and abroad, such as Japan and Brazil. However, if you are interested in co-investing in the form of research development, commercial patent development, or continuing to make product formulae under your brand, you may contact the firm through any method.

Reference

Zeng, Hua-Jin, et al. “A comparative study on the effects of resveratrol and oxyresveratrol against tyrosinase activity and their inhibitory mechanism.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 251 (2021): 119405.

Aftab, Nan, Kittisak Likhitwitayawuid, and Amandio Vieira. “Comparative antioxidant activities and synergism of resveratrol and oxyresveratrol.” Natural product research 24.18 (2010): 1726-1733.

Natakankitkul, Surapol, et al. “COSMECEUTICAL DEVELOPMENT OF OXYRESVERATROL FROM MAHAD (ARTOCARPUS LAKOOCHA ROXB.).” Thai J. Pharm. Sci 38 (2013).

Chung, Kyung-Ook, et al. “In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L.” Journal of Pharmacy and Pharmacology 55.12 (2003): 1695-1700.

Likhitwitayawuid, Kittisak. “Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems.” Molecules 26.14 (2021): 4212.